Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC023
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-11 10:00
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 36 individuals with a value less than 0.69 were subsequently diagnosed with PD. That is, 85.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.69 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 7, 'TN': 7, 'TP': 35, 'FP': 23}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 19, 'TN': 10, 'TP': 23, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.44
timePerCircleCoV 0.267414
timePerCircleSlope -0.0669486
meanError 3.01599
tremorFreq 6.44531
tremorRelPower 54.3939
tremorGyroAmpMean 0.0970761
tremorGyroAmpSlope 0.0118754
tremorGyroAmpCoV 0.300797
tremorCoordAmpMean 0.203164
tremorCoordAmpSlope 0.0207276
tremorCoordAmpCoV 0.301367
tremorAccAmpMean 0.156245
tremorAccAmpSlope 0.0177888
tremorAccAmpCoV 0.288587
tremorPcRelVar 0.657922
tremorPcX -0.897647
tremorPcY -0.440716

Circle Segment 1

Duration 5.76 s, Accuracy Estimate 2.815 (lower is better)

Circle Segment 2

Duration 4.12 s, Accuracy Estimate 2.163 (lower is better)

Circle Segment 3

Duration 3.32 s, Accuracy Estimate 2.838 (lower is better)

Circle Segment 4

Duration 3.08 s, Accuracy Estimate 3.422 (lower is better)

Circle Segment 5

Duration 3.68 s, Accuracy Estimate 2.859 (lower is better)

Circle Segment 6

Duration 2.84 s, Accuracy Estimate 3.389 (lower is better)

Circle Segment 7

Duration 3.0 s, Accuracy Estimate 2.976 (lower is better)

Circle Segment 8

Duration 2.76 s, Accuracy Estimate 2.781 (lower is better)

Circle Segment 9

Duration 3.0 s, Accuracy Estimate 3.151 (lower is better)

Circle Segment 10

Duration 2.84 s, Accuracy Estimate 3.765 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 21.352
timePerSpiralCoV 0.180992
timePerSpiralSlope 0.0198917
meanError 2.14358
tremorFreq 6.54297
tremorRelPower 49.122
tremorGyroAmpMean 0.106377
tremorGyroAmpSlope 0.00106412
tremorGyroAmpCoV 0.329697
tremorCoordAmpMean 0.151255
tremorCoordAmpSlope 0.000348047
tremorCoordAmpCoV 0.304231
tremorAccAmpMean 0.120296
tremorAccAmpSlope 0.000625887
tremorAccAmpCoV 0.298233
tremorPcRelVar 0.799127
tremorPcX 0.767417
tremorPcY 0.641148

Spiral Segment 1

Duration 20.28 s, Accuracy Estimate 2.094 (lower is better)

Spiral Segment 2

Duration 19.4 s, Accuracy Estimate 2.049 (lower is better)

Spiral Segment 3

Duration 21.8 s, Accuracy Estimate 2.367 (lower is better)

Spiral Segment 4

Duration 18.32 s, Accuracy Estimate 2.208 (lower is better)

Spiral Segment 5

Duration 18.8 s, Accuracy Estimate 2.041 (lower is better)

Spiral Segment 6

Duration 19.2 s, Accuracy Estimate 2.009 (lower is better)

Spiral Segment 7

Duration 30.52 s, Accuracy Estimate 2.686 (lower is better)

Spiral Segment 8

Duration 18.8 s, Accuracy Estimate 1.873 (lower is better)

Spiral Segment 9

Duration 25.6 s, Accuracy Estimate 1.893 (lower is better)

Spiral Segment 10

Duration 20.8 s, Accuracy Estimate 2.215 (lower is better)

Elel

eDurationMean 0.497439
eDurationStd 0.12463
eDurationStdnorm 0.250543
eDurationMedian 0.465
eDurationQuartdelta 0.09625
eDurationQuartdeltanorm 0.206989
eDurationKurt 7.14333
eDurationTrenddiff 0.0075
eDurationTrendratio 1.01622
eWidthMean 5.05098
eWidthStd 1.56577
eWidthStdnorm 0.309993
eWidthMedian 4.563
eWidthQuartdelta 2.2815
eWidthQuartdeltanorm 0.5
eWidthKurt 2.85114
eWidthTrenddiff -0.2925
eWidthTrendratio 0.939024
eHeightMean 10.51
eHeightStd 1.41756
eHeightStdnorm 0.134877
eHeightMedian 10.413
eHeightQuartdelta 1.19925
eHeightQuartdeltanorm 0.115169
eHeightKurt 7.24496
eHeightTrenddiff -0.0585
eHeightTrendratio 0.994382
eAspectMean 0.477593
eAspectStd 0.117928
eAspectStdnorm 0.24692
eAspectMedian 0.447059
eAspectQuartdelta 0.201015
eAspectQuartdeltanorm 0.449639
eAspectKurt 2.10723
eAspectTrenddiff -0.0165584
eAspectTrendratio 0.964033
eSlantMean 0.233232
eSlantStd 0.168036
eSlantStdnorm 0.720469
eSlantMedian 0.25
eSlantQuartdelta 0.27151
eSlantQuartdeltanorm 1.08604
eSlantKurt 2.4377
eSlantTrenddiff -0.0479042
eRtopMean 0.828348
eRtopStd 0.105281
eRtopStdnorm 0.127097
eRtopMedian 0.823529
eRtopQuartdelta 0.139557
eRtopQuartdeltanorm 0.169462
eRtopKurt 2.50817
eRtopTrenddiff 0.00286233
eRbotMean 0.379084
eRbotStd 0.250363
eRbotStdnorm 0.660443
eRbotMedian 0.333333
eRbotQuartdelta 0.291701
eRbotQuartdeltanorm 0.875102
eRbotKurt 3.72981
eRbotTrenddiff -0.0286195
eRrightMean 0.920378
eRrightStd 0.0462775
eRrightStdnorm 0.050281
eRrightMedian 0.93
eRrightQuartdelta 0.0429548
eRrightQuartdeltanorm 0.046188
eRrightKurt 3.12674
eRrightTrenddiff -0.00365823
eRleftMean 0.246141
eRleftStd 0.151602
eRleftStdnorm 0.615913
eRleftMedian 0.221053
eRleftQuartdelta 0.170088
eRleftQuartdeltanorm 0.769447
eRleftKurt 3.45851
eRleftTrenddiff 0.0224058
lDurationMean 0.722073
lDurationStd 0.200817
lDurationStdnorm 0.278112
lDurationMedian 0.66
lDurationQuartdelta 0.3025
lDurationQuartdeltanorm 0.458333
lDurationKurt 2.48409
lDurationTrenddiff -0.0275
lDurationTrendratio 0.958491
lWidthMean 10.5443
lWidthStd 2.24082
lWidthStdnorm 0.212515
lWidthMedian 10.179
lWidthQuartdelta 2.89575
lWidthQuartdeltanorm 0.284483
lWidthKurt 4.17134
lWidthTrenddiff -0.4095
lWidthTrendratio 0.960452
lHeightMean 22.153
lHeightStd 2.89094
lHeightStdnorm 0.130499
lHeightMedian 22.347
lHeightQuartdelta 3.276
lHeightQuartdeltanorm 0.146597
lHeightKurt 6.00333
lHeightTrenddiff -1.4625
lHeightTrendratio 0.936548
lAspectMean 0.477061
lAspectStd 0.0815498
lAspectStdnorm 0.170942
lAspectMedian 0.464481
lAspectQuartdelta 0.120967
lAspectQuartdeltanorm 0.260435
lAspectKurt 4.05802
lAspectTrenddiff -0.0274234
lAspectTrendratio 0.943152
lSlantMean 0.308661
lSlantStd 0.117944
lSlantStdnorm 0.382115
lSlantMedian 0.296804
lSlantQuartdelta 0.139914
lSlantQuartdeltanorm 0.471404
lSlantKurt 4.35963
lSlantTrenddiff -0.0255456
lRtopMean 0.911777
lRtopStd 0.0580432
lRtopStdnorm 0.0636594
lRtopMedian 0.91358
lRtopQuartdelta 0.0622347
lRtopQuartdeltanorm 0.0681218
lRtopKurt 4.04097
lRtopTrenddiff -0.023093
lRbotMean 0.267781
lRbotStd 0.188583
lRbotStdnorm 0.704244
lRbotMedian 0.223214
lRbotQuartdelta 0.266224
lRbotQuartdeltanorm 1.19268
lRbotKurt 7.01995
lRbotTrenddiff -0.0138357
lRrightMean 0.949982
lRrightStd 0.03879
lRrightStdnorm 0.0408323
lRrightMedian 0.956757
lRrightQuartdelta 0.0719308
lRrightQuartdeltanorm 0.0751819
lRrightKurt 2.07327
lRrightTrenddiff -0.0344172
lRleftMean 0.142412
lRleftStd 0.0798951
lRleftStdnorm 0.561013
lRleftMedian 0.141304
lRleftQuartdelta 0.113834
lRleftQuartdeltanorm 0.805596
lRleftKurt 3.31111
lRleftTrenddiff -0.0530192

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

FITTS Short Modified

meanTouchScore 0.864062
sumTouchScores 19.0094
meanMovementTime 0.826429
numTouches 22
undershootPercentage 0
overshootPercentage 22.7273

FITTS Long Modified

meanTouchScore 0.894044
sumTouchScores 12.5166
meanMovementTime 1.35846
numTouches 14
undershootPercentage 0
overshootPercentage 21.4286

ZigZag

numZigzags 5
timePerZigzagMean 18.72
timePerZigzagCoV 0.120068
timePerZigzagSlope -0.0470085
meanError 2.82207
tremorFreq 7.12891
tremorRelPower 42.809
tremorGyroAmpMean 0.107874
tremorGyroAmpSlope 0.00511203
tremorGyroAmpCoV 0.370251
tremorCoordAmpMean 0.17648
tremorCoordAmpSlope 0.00267956
tremorCoordAmpCoV 0.501379
tremorAccAmpMean 0.12333
tremorAccAmpSlope 0.00492353
tremorAccAmpCoV 0.323587
tremorPcRelVar 0.721388
tremorPcX 0.51703
tremorPcY 0.855968

ZigZag Segment 1

Duration 20.4 s, Accuracy Estimate 1.981 (lower is better)

ZigZag Segment 2

Duration 20.6 s, Accuracy Estimate 3.496 (lower is better)

ZigZag Segment 3

Duration 18.8 s, Accuracy Estimate 3.002 (lower is better)

ZigZag Segment 4

Duration 15.0 s, Accuracy Estimate 2.444 (lower is better)

ZigZag Segment 5

Duration 18.8 s, Accuracy Estimate 3.189 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 13.8333
timePerZigzagCoV 0.312222
timePerZigzagSlope -0.110293
zigzagHeightMean 75.7532
zigzagHeightCoV 0.0549769
zigzagHeightSlope 0.0179489
meanError 0.0501925
tremorFreq 6.83594
tremorRelPower 46.8116
tremorGyroAmpMean 0.11851
tremorGyroAmpSlope 0.000353807
tremorGyroAmpCoV 0.347844
tremorCoordAmpMean 0.196693
tremorCoordAmpSlope 0.00337562
tremorCoordAmpCoV 0.420307
tremorAccAmpMean 0.151591
tremorAccAmpSlope 0.00192633
tremorAccAmpCoV 0.391711
tremorPcRelVar 0.705698
tremorPcX 0.439152
tremorPcY 0.898413

ZigZag Offset Segment 1

Duration 16.32 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 2

Duration 21.32 s, Accuracy Estimate 0.053 (lower is better)

ZigZag Offset Segment 3

Duration 12.2 s, Accuracy Estimate 0.071 (lower is better)

ZigZag Offset Segment 4

Duration 10.44 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 5

Duration 9.84 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 6

Duration 12.88 s, Accuracy Estimate 0.046 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.69}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.6454498889437779}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8967911552406493}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}